Label: VARDENAFIL tablet, orally disintegrating

Erectile dysfunction is when a man has difficulty

Storage Condition	Recommended Temperature	Humidity	Additional Notes
Standard Storage	15-30°C (59-86°F)	< 70%	Keep away from light
Protect from moisture	-	Keep in a dry place	Keep in original container
Keep out of reach of children	-	-	Safety measure

achieving or maintaining an

Interacting Drug	Effect on Vardenafil	Potential Risk	Management
Nitrates	Potentiates effects	Severe hypotension	Avoid concurrent use
CYP3A4 Inhibitors (e.g., Ketoconazole)	Increased levels	Increased side effects	Dose reduction
Alpha-blockers	Additive hypotension	Monitor blood pressure	Administer with caution
Other PDE5 inhibitors	Cumulative effects	Increased adverse effects	Use with caution or avoid

erection sufficient for sexual activity.

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I am Interested Request a call back We Are a Global Leader in Trusted Pharmaceutical ExportsAt INSTEAD MEDEX, we are proud to be a globally recognized, trusted supplier of high-quality pharmaceutical products. I am Interested Request a call back Vilitra 20 Tablet may be taken on an empty stomach or with a meal. It vardenafil cost should be strictly taken as advised by your doctor. The medicine will only help you to get an erection if you are sexually stimulated. You should take it about one hour before you plan to have sex.

Mechanism of Action

The amount of time it takes to work varies from person to person, but it normally takes between 30 minutes and one hour. Only take it if you need it and it has been prescribed to you by a doctor.The most common side effects of this medicine are flushing, headache, dizziness, blurred vision, muscle pain, stomach upset, nasal congestion, and rash. Talk to your doctor if the side effects bother you or will not go away.This medicine is not intended for use by women and men should avoid using any other medicines to treat impotence without talking to a doctor. It can be dangerous to take it along with medicines called nitrates (often given for chest pain). Do not take this medicine if you have severe heart or liver problems, if you have recently had a stroke or heart attack or if you have low blood pressure.

Other Interactions

Let your doctor know if you suffer from these or any other health problems before taking it. You should not drive if this medicine makes you feel dizzy. Avoid drinking alcohol while taking this medicine as it can lead to side effects. I am Interested Request a call back I am Interested Request a call back We Are a Global Leader in Trusted Pharmaceutical ExportsAt INSTEAD MEDEX, we are proud to be a globally recognized, trusted supplier of high-quality pharmaceutical products. I am Interested Request a call back I am Interested Request a call back I am Interested Request a call back I am Interested Request a call back I am Interested Request a call back We Are a Global Leader in Trusted Pharmaceutical ExportsAt INSTEAD MEDEX, we are proud to be a globally recognized, trusted supplier of high-quality pharmaceutical products. vardenafil works by increasing blood flow to

Parameter	Result	Notes
Absorption Time	30-60 minutes	Time to peak plasma concentration (Tmax)
Bioavailability	~15%	Percentage of dose reaching systemic circulation
Half-life	4-5 hours	Duration of effect
Metabolism	Liver (CYP3A4 enzyme)	Mainly via hepatic pathways
Excretion	Feces (~60%), Urine (~20%)	Primary routes

the penis, which helps

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to improve erectile function.

12.2 Pharmacodynamics

I am Interested Request a call back I am Interested Request a call back I am Interested Request a call back I am Interested Request a call back We Are a Global Leader in Trusted Pharmaceutical ExportsAt INSTEAD MEDEX, we are proud to be a globally recognized, trusted supplier of high-quality pharmaceutical products. I am Interested Request a call back 10 mg orally, one-hour prior sexual activity It may decrease to 5 mg or may increase to 20 mg Based on effectiveness and tolerance, do not exceed more than 1 dose per day 10 mg orally, one-hour prior sexual activity It may decrease to 5 mg or may increase to 20 mg Based on effectiveness and tolerance, do not exceed more than 1 dose per day For <65 years A film-coated tablet 10 mg orally an hour before intimacy May be decreased to 5 mg or increased to 20 mg, based on the efficacy and tolerance Do not exceed more than 1 dose/day 10 mg orally disintegrating tablet is placed on the tongue an hour before intimacy Do not exceed more than 1 dose/day The medication is not interchangeable with 10 mg of the film-coated tablet For >65 years 5 mg initial dose As AUC and Cmax are higher in older adults as compared to young men vardenafil is a medication used to treat erectile dysfunction (ED) in men. It belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors, which work by increasing blood flow to the penis, leading to improved erectile function. Increasing blood flow to the penis: vardenafil relaxes the smooth muscle cells in the blood vessels that supply the penis, allowing for increased blood flow. Improved erectile function: By increasing blood flow to the penis, vardenafil can help men with ED achieve and maintain an erection.

What are the serious side effects of vardenafil?

Shorter onset time: vardenafil has a shorter onset time than other PDE5 inhibitors, meaning it can take effect more quickly after administration. Treatment of erectile dysfunction: vardenafil is premature ejaculation pills primarily used to treat ED in men. Pulmonary arterial hypertension: vardenafil has also been used off-label to treat pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the arteries that supply the lungs. Raynaud’s phenomenon: vardenafil has also been used off-label to treat Raynaud’s phenomenon, a condition in which the blood vessels in the fingers and toes constrict in response to cold or stress. There is no blackbox warning for this drug The drug is contraindicated in patients hypersensitive to vardenafil.

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Excretion of vardenafil in breastmilk is unknown Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester. Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a product in humans; Pregnant women must take care of the potential risks. Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms. However, despite potential dangers may be used only in emergency cases for potential benefits. Category X: Drugs listed in this category outweigh risks over benefits. vardenafil belongs to a class

• Vardenafil 10 mg may be used by men over 18 years.
• The medication is not approved for use in women or children.
• May be contraindicated in patients with certain eye conditions.
• Use caution if you have a history of stroke.
• The drug’s chemical action involves improving blood flow.
• It is important to distinguish ED causes before treatment.
• Use only medications prescribed by a healthcare professional.
• Avoid combining with other erectile dysfunction medications.
• Keep medication out of sunlight and moisture.
• Seek emergency medical help for severe side effects.

of drugs called phosphodiesterase type

What can cause erectile dysfunction?

The drug is not for pregnant women. Category N: No data is available for the drug under this category. vardenafil is a medication that belongs to the class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. It works by blocking the action of the enzyme PDE5, which usually breaks down cyclic guanosine monophosphate (cGMP) in the smooth muscle cells lining the blood vessels of the penis. cGMP is a molecule that acts as a messenger, signaling the smooth muscle cells to relax, which allows blood to flow into the penis, leading to an erection.

Does vardenafil interact with foods or drinks?

By blocking PDE5, vardenafil increases cGMP levels, improving blood flow to the penis and improving erectile function. The pharmacodynamics of vardenafil involves its ability to inhibit PDE5, which results in increased levels of cGMP and improved erectile function. vardenafil has more excellent selectivity for PDE5 than other PDE isoforms, reducing the likelihood of side effects. The onset of action is 60 minutes The peak plasma time is 30-120 min The drug is metabolized in the liver by CYP2C9 and CYP3A4 The half-life is 3-6 hours The rate of total body clearance is 56 L/hr The drug is excreted 95% in feces and 5% in urine vardenafil is a medication typically taken orally, about 30 to 60 minutes before sexual activity. The medication is in tablet form and should be taken with a full glass of water.

Pulmonary Arterial Hypertension (Orphan)

The recommended starting dose of vardenafil is 10 mg, although the dose may be adjusted based on individual response and tolerability. The maximum recommended dose is 20 mg per day. vardenafil should not be taken more than once per day, and it should not be taken with grapefruit juice or high-fat meals, as these can affect the absorption and effectiveness of the medication. Individuals taking vardenafil should avoid alcohol and not take the medication with other drugs that can interact with it, such as nitrates or nitric oxide donors. vardenafil is used to treat erectile dysfunction (ED) in adult men. 5 (PDE5) inhibitors, which also

• Some users may experience mild flickering vision episodes.
• The efficacy of vardenafil varies between individuals.
• The medication is available in various dosage forms.
• Always follow the specific instructions provided.
• Avoid taking vardenafil with high-fat meals to speed absorption.
• Do not take vardenafil if allergic to its ingredients.
• The drug may cause a temporary burning sensation.
• Use caution in patients with a history of priapism.
• Avoid combining vardenafil with certain herbal supplements.
• Consult your doctor about any ongoing health treatments.

include sildenafil (Viagra) and tadalafil (Cialis).

7.3 Effects of Vardenafil on Other Drugs

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What should I know about vardenafil before taking it?

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What is the dosage for vardenafil?

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